الفهرس 
Background About Disseminated Intravascular CoagulationOnly 14 pages are availabe for public view
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Abstract
Background: Disseminated intravascular coagulation (DIC) is characterized by systemic activation of blood coagulation, which results in generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction syndrome (MODS). Consumption and subsequent exhaustion of coagulation proteins and platelets (from ongoing activation of coagulation) induce severe bleeding, though micro clot formation may occur in the absence of severe clotting factor depletion and bleeding.
DIC usually results from exposure of tissue factor to blood, initiating the coagulation cascade. DIC occurs most often in: obstetric complications, infection particularly with gram-negative organisms, cancer and shock.
Aims: The aim of this essay is to discuss the recent advances in disseminated intravascular coagulation especially in diagnosis and treatment.
Conclusion: Disseminated intravascular coagulation (DIC) is characterized by systemic activation of blood coagulation, which results in generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction syndrome (MODS).
And recently it is clear that the vascular endothelium performs its essential function of regulating systemic blood flow by finely tuning the diameter of blood vessels and regulates vascular tone by releasing vasodilators including nitric oxide and prostaglandin I2 as well as vasoconstrictors such as endothelin and platelet-activating factor. Uncontrolled and spreading systemic inflammatory responses to microbial infections play critical roles in the pathogenesis of sepsis.