الفهرس 
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Abstract
The study included 244 men out of 716 men presented to the University
hospitals after ethical approval and informed consent.
They were allocated into:
I- Healthy potent men (n=52)
II- Men with erectile dysfunction (ED) responders for sildenafil (n=96)
III- Men with ED non-responders for sildenafil (n=96)
Inclusion criteria for PDE-5Is non-responders:
An inadequate erectile response after 6 attempts using high tolerated dose
(200 mg) with manufacturer’s guidelines in respect to time relative to meals,
associated medications and sexual stimulation / arousal.
Exclusion criteria:
Diabetes, smoking, hypertension, dyslipidemia, hypogonadism,
cardiovascular disorders, morbid obesity, hepatic or renal failure.
They were subjected to:
History taking, clinical examination, IIEF-5 questionnaire, estimation of
HO-1 GT repeats polymorphisms by PCR.
The results were as follows:
1. In ED men, SS genotyping demonstrated significant decrease whereas LL
genotyping demonstrated significant increase compared with potent controls. In
Summary
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addition, SL/LL genotyping demonstrated significant increase compared with
potent controls.
2. In potent controls, SS genotypes demonstrated significant increase whereas
LL genotypes demonstrated significant decrease compared with ED men nonresponders
to sildenafil citrate.
3. SL/LL genotyping demonstrated significant increase in ED men nonresponders
to sildenafil citrate compared with potent men.
4. In potent men, S allele frequencies demonstrated significant increase
whereas L allele frequencies demonstrated significant decrease compared with ED
men.
5. In ED men non-responders to sildenafil, S allele frequencies demonstrated
significant decrease whereas L allele frequencies demonstrated significant increase
compared with potent men and ED men responders for sildenafil.
6. HO-1 genotypes demonstrated significant negative correlation with IIEF-5
and nonsignificant correlation with age. IIEF-5 demonstrated significant negative
correlation with age.
Conclusion:
HO-1 GT repeats polymorphisms play a role of male sexual health being
significantly represented in men with ED non-responding for sildenafil citrate.