الفهرس 
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Abstract
Cinnamaldehyde is the organic compound which forms the taste and scent of cinnamon. Researches have proposed that cinnamon extract exerts chemopreventive properties such as anti-oxidative effects. Aim of the work: The purpose of this study was to investigate the effect of cinnamaldehyde (CIN) on 7, 12-Dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis on hamster cheek pouch (HCP) mucosa. Methods: Sixty male golden Syrian hamsters were selected and randomly divided into six equal groups. The hamsters of groups I, II and III received no treatment, DMBA and CIN respectively, for 16 weeks. Groups IV and V were handled as group II and concomitantly treated with CIN for the same period and additionally group V received CIN for other 16 weeks after the stoppage of DMBA application. group VI hamsters were handled as group III and additionally received DMBA for other 16 weeks after the stoppage of CIN supplementation. The buccal pouches were excised and prepared for regular H&E stain, PAS reagent, CD3 and PDGF immunohistochemical reactivity, and also for TEM. Results: group I and III HCPs revealed normal structural and architectural features. group II DMBA treated pouches exhibited squamous cell carcinoma while groups IV, V, and VI showed decreased signs of epithelial dysplasia and less extensive invasion of carcinoma to the underlying connective tissue when compared to group II. Conclusion: CIN has a beneficial role as a chemopreventive agent as it causes regression of cancer progression.