الفهرس 
Polycystic ovary syndrome (PCOS)Only 14 pages are availabe for public view
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Abstract
Polycystic ovary syndrome (PCOS) is a common gynecologic endocrinopathy and affects 6.8%–18% of reproductive women .The European Society of Human Reproduction and Embryology and the American Society for Reproductive Medicine sponsored in Rotterdam in 2003 issued that the diagnosis of PCOS should be made when two of the following characteristics are satisfied: (1) oligoamenorrhea and/or anovulation. (2) the presence of clinical or biochemical hyperandrogenism and (3) polycystic ovarian morphology on ultrasound after excluding other related diseases that can induce ovarian dysfunction and hyperandrogenism .Clomiphene citrate is still considered first-line therapy for ovarian stimulation in PCOS. Aromatase is a microsomal enzyme that mediates conversion of androstenedione to estrogen, several studies have demonstrated the effectiveness of aromatase inhibitors in induction of ovulation. Letrozole is a newly designed selective aromatase inhibitor, which can be used to induce ovulation in infertile women with PCOS. Aim: The aim of this study is to compare the effectiveness of letrozole versus clomphine citrate for ovulation induction in infertile women with PCOS. One hundered and ten infertile women diagnosed as having PCOS were distributed randomized in two groups (Letrozole or Clomiphene citrate group) 55 women in each group. received either letrozole 2.5 mg or Clomiphene citrate 50 mg twice daily from 2nd to 6th day of the cycle. 46 (83.6%) women from the letrozole group ovulated during the observation period as 36 (65.45%) women had one mature follicle and 10 (18.18%) women had 2 or more mature follicles. While 33 (60%) women from the clomiphene citrate group ovulated during the observation period as 25 (45.45%) women had one mature follicle and 8 (14.54%) women had 2 or more mature follicles. the difference showing statistically significane. Conclusion: Letrozole has efficacy as that of clomphine citrate in induction of ovulation in PCOS, and has the following beneficial effects, Less side effects, Better endometrial thickness and Predomintaly monofollicular ovulation.