الفهرس 
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Abstract
This study aimed to assess vitamin D receptor (VDR) polymorphisms in PDE-5 inhibitors non-responders. In all, 288 men presented to the University hospitals after ethical approval and informed consent.
They were allocated into:
I- Healthy potent men (n=144)
II- Men with ED non-responders for sildenafil (n=1440)
Inclusion criteria for PDE-5Is non-responders:
An inadequate erectile response after 6 attempts using high tolerated dose (100 mg) with manufacturer’s guidelines in respect to time relative to meals, associated medications and sexual stimulation/ arousal.
Exclusion criteria:
Diabetes, smoking, hypertension, dyslipidemia, hypogonadism, cardiovascular disorders, morbid obesity, hepatic or renal failure.
They were subjected to:
History taking, clinical examination, IIEF-5 questionnaire, estimation of serum vitamin D, VDR and VDR genotyping by PCR.
Summary
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The results were as follows:
1. In ED men non-responders for sildenafil, the mean score of IIEF-5, VDR as well as serum vitamin D levels demonstrated significant decrease compared with potent controls.
2. ED men non-responders for sildenafil citrate demonstrated significant decrease of FF genotypes and significant increase of Ff and ff genotypes compared with potent controls.
3. Ff/ff genotypes demonstrated significant increase in ED men non-responders to sildenafil citrate compared with potent men. (relative risk---).
4. VDR gene Fok1 polymorphism genotypes demonstrated significant negative correlation with IIEF score, VDR and serum vitamin D and significant positive correlation with age. Serum vitamin D as well as VDR demonstrated significant positive correlation with IIEF score, VDR and significant positive correlation with age.
Conclusion
Serum vitamin D as well as VDR polymorphism plays a role of male sexual health being significantly represented in men with ED non-responding for sildenafil citrate.