الفهرس 
?INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 171 |  |  |
| | | from | 171 | | |
Abstract
Background: Clinically isolated syndrome (CIS) converted to multiple sclerosis (MS), in magnetic resonance imaging (MRI) and clinical feature are used to predict risk of conversion to MS. Objective: To study the clinical, MRI, VEP and the role of vitamin D in the conversion of CIS to clinically definite MS. Methods: This is longitudinal cross control study conducted on 43 patients with diagnosed as CIS according to McDonald’s criteria (2010) the patients were recruited from Neurology Department, Fayoum University from July 2014 to July 2015 and thirty healthy control were selected for comparison of PASAT and vitamin D level. All patients underwent full clinical examination, vitamin D level assessment followed-up for one year. Result: 8 patients (18.3%) were converted to MS after one year follow-up the patients with CIS had lower vitamin D level compared to controls, multivariate regression studies showed that CIS patients that presented with optic neuritis (ON), higher MRI T2 lesion load and lower vitamin D level were at higher risk for conversion to MS. Follow-up MRI showed heavier load of T2 lesions as compared to stable CIS (<0.05), again vitamin D levels in CDMS group were lower in comparison to group Ia (<0.05). the cut-off point was 8.3 ng/l. Conclusions: The low level of vitamin D patients with CIS could predict early conversion to clinically definite MS particularly in the patients presented with optic neuritis and higher MRI T2 lesion load.