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Abstract Unexplained infertility is one of the most common diagnosis in a fertility clinic with the prevalence of 15-30%. It is not an absolute condition but a relative inability to conceive, and while many of these couples may conceive without treatment, treatment will often hasten conception. The diagnosis is possible only after a complete infertility evaluation, including a physical examination of both partners, has been performed. The basic infertility work-up includes demonstration of 1) Normal findings in semen analysis. 2) Patent fallopian tubes. 3) Ovulation and normal luteal phase. This study was designed to assess the role of saline infusion hysterosonography in defining the uterine cavity abnormalities diagnosed by hysteroscopy in unexplained infertile women. Fifty women with unexplained infertility were included in this study. Hysteroscopy was done as routine procedure for uterine cavity assessment. Patients agreed to have an ultrasound assessment of uterine cavity with the use of saline as the contrast medium (Saline infusion hysterosonography, SIS) beside the hysteroscopic assessment. Both hysteroscopy & SIS procedures |