الفهرس 
chronic hepatitis C virus and liver fibrosisOnly 14 pages are availabe for public view
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Abstract
Serum bile acids (SBAs) are commonly elevated in cholestatic liver diseases, but it is unclear if SBA levels are also elevated in non-cholestatic chronic liver diseases and whether levels correlate with disease severity.Elevation of ALP is observed in patients who have some form of extra hepatic and intra hepatic bile duct obstruction. Any mechanism that impaired excretion of ALP in bile will result in regurgitation of enzyme into circulation via the hepatic sinusoid. The increased cholestatis stimulates the synthesis of ALP by the bile ductules cell providing more ALP which ultimately enters the bloods, the amphillic nature of bile salts facilitates the release of ALP from its membranes bound site and entry into blood.A proportional relationship is found between serum lipid profiles and hepatitis C viral load in patients with genotype 2 infection.Aim of the work: To assess the role of level of bile acid,lipid profile and alkaline phosphatase as a non-invassive method in relation to liver fibrosis in patient with chronic hepatitis C virus (HCV) .Method: The study included: 100 patients with HCV detected by HCV antibody who underwent laboratory tests(Serum bile acid: Alkaline phosphatase , CBCs ,AST ALT and Serum bilirubin, lipid profile (cholesterol, triglyceride, HDL ,LDL, VLDL)), Pelvi abdominal ultrasound and Liver biopsy.Results: There was statistically significant increase (p<0.001) of creatinine, bile acid level bilirubin, AST, ALT, AST/ALT ratio and ALP between patients in relation to stages of liver fibrosis, also high statistically significant in decrease (p<0.001)of Hb, WBCs, platelets and albumin level between patients in relation to stages of liver fibrosis, Lipid profile has a U shaped curve as it increase from F0 to F2 then decrease from its previous values in F3.
Conclusion:As a noninvasive method AST/ALT ratio, ALP, bile acid level and lipid profile can be used as a predictor of liver fibrosis severity in patients with chronic hepatitis C.