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Abstract Introduction: Oncologic emergencies can occur at any time during the course of a malignancy, from the presenting symptom to end-stage disease. Although some of these conditions are related to cancer therapy, they are by no means confined to the period of initial diagnosis and active treatment. Treatment requires systematic evaluation and early empirical antibiotics. Hypercalcemia of malignancy is the most common metabolic emergency in cancer patients. Non-specific clinical features may cause delay in diagnosis and increase morbidity and mortality. Aims: The aim is to discuss oncological diseases in ICU regarding pathophysiology, complications, early detection and management. Summary: Over the last 15 years, the management of critically ill cancer patients requiring intensive care unit (ICU) admission has substantially changed. High mortality rates (75-85%) were reported 10-20 years ago in cancer patients requiring life sustaining treatments, especially when mechanical ventilation was needed or in recipients of hematological stem cell transplantation. Oncologic emergencies can threaten the well-being of almost any patient with a malignancy. Because these conditions span the chronologic spectrum of a disease’s natural history, from initial presentation to late recurrence to end-stage disease, all clinicians should be familiar with the manner in which these conditions emerge, as well as understand the methods for their prompt assessment and treatment. Prompt identification and intervention in these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. |