الفهرس 
Diabetes Mellitus
Microvascular complicationsOnly 14 pages are availabe for public view
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Abstract
The present study aims to study the serum cystatine C level in patients with type 2 diabetic nephropathy.The present study was conducted on 40 subjects. Thirty patients with diabetes were selected from outpatient diabetic clinics in Internal Medicine Department at Tanta University hospital. In addition,ten apparent healthy subjects were included as a control group.All patients and controls included in the study were subjected to the
following:Full history taking, complete clinical examination and laboratory
investigations (Serum blood urea nitrogen,Serum creatinine, estimated GFR, Albumin/Creatinine Ratio,Measurement of Cystatine C by ELISA )The main findings can be summarized as follows:Family history, obesity and overweight are risk factor for DM. More than half of patients had diabetes since 5 years or less.The majority of patients used OHA to manage diabetes and most of patients check blood glucose regularly Serum urea and creatinine was found to be higher in diabetic patients than in their non-diabetic counterparts.Serum cystatine C and creatinine were significantly higher in macroalbuminuric patients compared to norm-albuminuric or microalbuminuric patients. The serum level of cystatine C was positively correlated with age and diabetes duration whereas sex and body mass index did not affect cystatine C level. Serum cystatine C had significantly higher diagnostic accuracy in distinguishing patients with nephropathy than serum creatinine. In conclusion, the results of this study suggest that cystatine C measurement in serum is a useful, practical, non-invasive tool for the evaluation of renal involvement in the course of diabetes,especially in normal albuminuric patients. Further investigations with a larger sample size and a prospective design are required to confirm the potential application of cystatine C as a useful biomarker for the early detection of diabetic nephropathy,Christopher sorli study