الفهرس 
Genetic PredispositionOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is a group of metabolic disorders characterized by
hyperglycemia resulting from defects in insulin secretion, insulin action, or both.
The
chronic hyperglycemia of diabetes is associated with long term damage,
dysfunction, and failure of various organs, especially the eyes kidneys, nerves,
heart, and blood vessels .
Diabetes Mellitus type Two previously named Non
-
Insulin
-
Dependent
Diabetes
Mellitus (NIDDM) or adult
-
onset Diabetes
–
is a metabolic disorder
that is characterized by high blood glucose in the context of insulin resistance
and relative insulin deficiency .
Osteocalcin, also known as bone gamma
-
carboxyglutamic acid
-
containing
prot
ein (BGLAP), is a noncollagenous
protein
found in bone and
dentin
. Because
it has
gla domains
, its synthesis is
vitamin K
dependent. In humans, the
osteocalcin is encoded by the BGLAP
gene
. Its receptor is
GPRC6A
.Total serum
osteocalcin concentrations in humans are inversely associated with measures of
glucose metabolism.
The aim of the present study was to asses
s the level of osteocalcin in type
2 diabetes mellitus patients.
The studied groups were classified as
follows:
group 1 :
55 patients with type 2 diabetes mellitus patients.
group 2:
30 healthy volunteers as control.