الفهرس 
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Abstract
Hepatitis C infection is a pressing national problem for Egypt with highest recorded prevalence world wide. It has been acknowledged that the patients with various genetic backgrounds, which influence the quality of host immune response, may result in the different outcomes of HCV infection. The aim of this study was to assess the association between the genetic polymorphism of Toll-like receptors 3 and 7 and the susceptiblity to chronic infection with HCV. To achieve this goal 135 Egyptian families with an HCV positive index member were enrolled in our study. Subjects of the study were classified into three distinctive groups according to their infection state; HCV infected group of 216 subjects, spontaneous clearance group of 108 subjects, and HCV negative group of 298 subjects. The study design and investigators were reviewed by the faculty ethical committee and all patients signed informed consent prior to their enrollment to the study.