الفهرس 
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Abstract
Multiple sclerosis is an autoimmune condition in which the immune system attacks the central nervous system (CNS),leading to demylination. It may cause numerous physical and mental symptoms, and often progresses to physical and cognitive disability. Disease onset usually occurs in young adults, and is twice as common in females. It typically presents in young adults between 20 and 50 years of age, with a peak occurring at 30 years of age, although childhood or older age cases occasionally occur , Its prevalence 203 per 100,000 population in 2014.
Major depression (MD) is the most common neuropsychiatric disorder encountered in MS, its prevalence close to 50%, i.e. three times higher than in the general population, depending on the criteria used and the clinical settings of the studies (community, outpatients or tertiary clinics). Cognitive deficits in multiple sclerosis (MS) are known to be a common feature of the disease. Presently, up to 65% of patients are affected and many report that they find the symptoms troublesome. Cognitive impairment is occurring at all stages of the disease, and can be a major source of vocational disability, social impairment, and impoverished quality of life.
The aim of the work to study the relation between the disability, cognitive impairment, depression, and MRI findings in patients with multiple sclerosis.
This study was conducted on 40 multiple sclerosis patients of both sexes and 20 healthy controls.
The results reveal that Our study showed from our sample that the most common presentation hemihypothesia and the number of attacks ranging from 2-10 attacks in disease duration from 2-15 years, and the disease was more prevalent in females
Depression was present in 22 patients (55%) According to beck depression scale which showed that moderate depression was the commonest between depressed the MS patients.
There was significant cognitive impairment in multiple sclerosis patients in Memory, Comprehension, Attention, Visuospatial perception , language and abstract reasoning compared to the control group
Quality of life is affected negatively with depression as we found a statistically highly significant inverse correlation between depression tested by (BDI) and QOL.
Quality of life was found to be impaired by neurological disabilities detected by EDSS .
Also quality of life was affected by the type of medication received, as patients received interferon had better quality of life than those who did not received it.
from our findings on MRI In depressed patient there was a correlation between depression and frontotemporal lesion area in mm2 (lesion burden) as well as corpus callosum lesion area
Also we found a correlation between cognitive impairment according to WAIS and lesion area in the periventricular, corpus callosum and left temporal region in MRI of the brain.