الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
In The Present Study, The Possible Protective Effects And The Underlying Mechanism Of Enoxaparin And Diclofenac On L-Asparaginase Induced AP In Rats. To Fulfill The Aim Of This Study, Sets Of Experiments Were Conducted; Biochemical Set To Investigate The Underlying Mechanisms Behind Acute Pancreatitis, Confirmed By Histopathological Study.
To Design The Study; 64 Animals Were Randomly selected And Allocated Into Eight Groups, 8 Rats Each And Treated With Either L-Asparaginase Or Enoxaparin Or Diclofenac For 5 Days As Follows; group 1: Rats Were Given Normal Saline 0.9% I.M., group 2: Rats Were Given L-Asparaginase Enzyme (1000 I.U/ Kg, I.M), group 3: Rats Were Given Enoxaparin (100 I.U/Kg, S.C.) , group 4: Rats Were Given Diclofenac (2 Mg/Kg, I.P.), group 5: Rats Were Given Enoxaparin (100 I.U/Kg, S.C) And Diclofenac (2 Mg/Kg, I.P), group 6: Rats Were Given L-Asparaginase Enzyme (1000 I.U/ Kg, I.M) And Enoxaparin (100 I.U/Kg, S.C), group 7: Rats Were Given L-Asparaginase Enzyme (1000 I.U/ Kg, I.M) And Diclofenac (2 Mg/Kg, I.P), group 8: Rats Were Given L-Asparaginase Enzyme (1000 I.U/ Kg, I.M) And Diclofenac (2 Mg/Kg, I.P., For 5 Days) And Enoxaparin (100 I.U/Kg, S.C).
The Results Of The Present Study Can Be Summarized As Follows: Treatment Of L-Asparaginase Caused Severe Pancreatic Injury, Which Was Reduced To The Normal Levels By Treatment With Enoxaparin And/Or Diclofenac. This Is Proved By The Histopathological Examination.
To Investigate The Possible Mechanisms Underlying The Protective Effects Of Enoxaparin And/Or Diclofenac During L-Asparaginase Treatment, Oxidative Stress And Immune Cell Infiltrations Were Studied. Oxidative Stress Was Elevated And Pancreatic Tissue Was Highly Infiltrated With Immune Cells During Treatment With L-Asparaginase And Normalized Through Treatment With Enoxaparin And/Or Diclofenac.
After Confirming The Different Properties Of Enoxaparin And Diclofenac The Next Step Was To Clarify The Possible Role Of The Drugs In Restoring Or Improving The Hypertriglyceridemia Induced During L-Asparaginase Administration. This Study Showed That L-Asparaginase Didn’t Change The Levels Of TC, HDL, And LDL But Increased The TG Level. Enoxaparin Reduced TG Level, Without Any Effect On The Level Of TC, HDL, And LDL. On The Other Hand, Diclofenac Didn’t Show Any Change In The Level Of These Parameters.