الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Recurrent pregnancy loss (RPL) is defined as two or more failed clinical consecutive pregnancies as documented by ultrasonography or histopathologic examination before 20 weeks gestation.
Many accepted etiologies for RPL are present. These include chromosomal abnormalities, certain uterine anatomic abnormalities, endocrine disorders, thrombophilias, immunologic abnormalities, infections, and environmental factors. After evaluation for these causes approximately more than half of all cases remain unexplained, hence the question whether there is an overlapping between the etiological pathways.
Although pregnancy is a hypercoagulable state, the haemostatic system plays an important role in the successful completion of implantation and placentation. However, prothrombotic changes and increased inflammation can lead to thrombotic effect for these processes and may cause pregnancy loss.
The objective of this study was to measure Platelet indices namely: platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), red cell indices namely: RPL count (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and hematocrit (HCT) between pregnant women with RPL and pregnant women with no history of RPL, as it can be used for prediction of pregnancy loss and high risk pregnancy using economical and easily analyzers.
The study was conducted on 80 pregnant females selected from the antenatal clinic of El Shatby Maternity University Hospital during the period from January 2016 until August 2016. Those women were divided into two groups:
• group A: included 40 pregnant women who had no history of recurrent pregnancy loss (control group).
• group B: included 40 pregnant women who had a history of recurrent pregnancy loss.
Recurrent pregnancy loss was defined as two or more consecutive pregnancy loss (<20 weeks), women who had experienced RPL due to uterine anomalies were excluded.
After taking an informed consent from all pregnant women involved in the study, they were subjected to complete history taking, clinical examination, and ultrasonographic evaluation of their pregnancy at the time of presentation. A complete blood count test was performed, via an automated hematological analyzer that automatically measures several blood cell parameters, including Platelet indices and RPL indices.
The present study found that there was a statistically significant difference among both group regarding PLT, PCT, MPV, and HCT discussed as below:
The results of the present study support that increased MPV as well as increased HCT and PCT values in patients with RPL than those of patients in the control group leads to thrombosis, which in turn leads to micro-emboli in the uteroplacental circulation. Also, decrease PLT count due to increase placental PLT aggregation lead to thrombosis and so pregnancy loss.
The present study concluded that the use of platelet indices and red cell indices may be useful in predicting high risk pregnancy (pregnancy loss), and so pregnancy outcome, but not a diagnostic test for the cause.
However, more studies needed with larger sample size, multicenter randomized control study with the consideration of the thromboembolic precipitating risk factors, such as immobilization, surgery, or trauma.