الفهرس 
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Abstract
Background: Iliac crest bone graft (ICBG) was the gold standard graft for lumbar fusion. However, there are many complications associated with use of autograft in lumbar fusion include; donor-site morbidity, pseudoarthrosis, and limited amount of bone can be harvested. To avoid and prevent the previous complications, rhBMP-2 are possible substitute for autogenous bone graft.
The aim of the work: Compare the outcomes of recombinant human bone morphogenetic protein-2 (rhBMP-2) and autogenous iliac crest bone graft (ICBG) in lumbar spinal fusion.
Materials and Methods: we conducted a comperhensive electronic search in Pubmed, MEDLINE and Chocrane library databases, for Randomized control trials studies that comparing the outcomes of rhBMP-2 and ICBG in lumbar spinal fusion surgery.
Results: 12 studies met our iclusion criteria. All studies demonstrated that the fusion rate (radiographic outecome) at the end of follow up was higher in rhBMP-2 group compared to ICBG group. The clinical outecome (ODI score) showed there was no difference in the improvement between the groups. The operative time was shorter and blood loss was lesser in the rhBMP-2 group compared to the ICBG group in all studies.
Conclusion: The use of rhBMP-2 as a substitute to ICBG in lumbar spinal fusion can increase the fusion rate. Also decrease the blood loss and the operative time. But, the clinical outcome similar between groups although a favorable trend in the rhBMP-2 group was found.