الفهرس | Only 14 pages are availabe for public view |
Abstract The rate of some bacterial or viral agents in cause of ITP is well known. It has been demonstrated that the mimicry of human antigen by infectious agents represents the mechanism underlying this phenomena. In our study, there is a strong association between H. pylori infection and immune thrombocytopenia where (69.25%) are positive for H. pylori (Ab) in study group (ITP) versus (26.67%) in control group with significant difference (P=0.003). Also ( 61.53%) are positive for H. pylori (Ag) versus (26.67%) in control group with significant difference (P=0.002).Also there is significant increase in the prevalence of H. pylori infection in study group A1 which represent children (78.1%) versus (60.6%) in study group A2 which represent adult. In our study only 5 patients are positive for H. pylori (Ab) but negative for H. pylori (Ag) that may indicate prior or current infection and that the main advantages of antibody based are their simplicity, low cost, speed and minimal patient discomfort. Recommendations Examining the infection H. pylori infection for all patients with immune thrombocytopenia through measurement of H. pylori (Ab) in the serum and H. pylori (Ag) in the stool, as there is a strong association between H. pylori infection as there is strong association between H. pylori infection and immune thrombocytopenia and there is an evidence that eradication of H. pylori infection result in improvement of platelet count and complete remission. |