الفهرس 
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Abstract
It was conducted to evaluate the histopathological effect of local statin injection on the bone surrounding mini-implants in rats.Thirty-six male Albino rats, average weight 250 g were used in this study. They were divided into three groups:- First group (Control group): twelve rats in which the screws were inserted in the maxillae without any injections.- Second group (Study group I: vehicle group): twelve rats in which the screws were inserted in the maxillae with 0.25 ml polyethylene glycol (PEG) 400 injected around screws daily for 14 days. - Third group (study group II: simvastatin (SIM) group):twelve rats in which the screws were inserted in the maxillae with 0.5 mg simvastatin injected around screws daily for 14 days.After thirty days from the first injection, the rats in all groupswere euthanized, dissected and the samples were collected and processed for histological examination. Based on the results of the current study the following conclusions could be obtained:
1) Simvastatin injection is a safe effective method in promoting bone healingfollowing mini-implant insertion.2) Simvastatin injected animals had significant histological differences in bone healing around mini-implants.3) The results confirmed the role of simvastatin as anabolic agent for bone regeneration.4) Injection delivery systemsfor simvastatin may provide a comfortable and flexible method not only to initiate bone healing around mini-implants, but also to increase bone density around them.