الفهرس 
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Abstract
Vesicular systems are novel means of drug delivery in controlled manner, to enhance bioavailability and get therapeutic effect over a longer period of time. Niosomes are such hydrated vesicular systems obtained by hydration of synthetic non-ionic surfactants along with cholesterol or other lipids delivering drug to targeted site. The structure and properties of niosomes are similar to those of liposomes, but the chemical stability as well as the relatively low cost of materials used to prepare niosomes makes them more applicable than liposomes for industrial productions in pharmaceutical and cosmetic applications. Their in-vivo behaviour follows the pattern of other colloidal drug delivery systems, which are biocompatible, biodegradable and non-immunogenic.
Candida albicans and limited number of other Candida species are part of the normal commensal flora of mucosal surfaces. When either local or systemic host defence mechanisms are impaired, Candida species can cause oropharyngeal, esophageal or vulvovaginal candidiasis. Also, in susceptible hosts, Candida albicans can penetrate the gastrointestinal mucosa and enter the bloodstream causing haematogenous disseminated candidiasis. When this organism proliferates, it may produce symptomatic infections ranging from relatively trivial conditions, such as oral and genital thrush, to crucial, systemic super infections in immunodepressed and chemotherapy patients.Antifungal agents are used to treat fungal infections and also to stop their development. There are several classes of antifungal agents which are: polyene, triazole, thiazole, imidazole, allylamines and echinocandins. Different types of topical effective antifungal compounds have been used in the treatment of a variety of dermatological skin infections. Azole antifungals such as clotrimazole, econazole nitrate and fluconazole are the first line treatments for various fungal infections.
Clotrimazole is a lipophilic imidazole derivative with a broad spectrum antimycotic effect that acts against fungi by inhibiting ergosterol synthesis, which in turn leads to structural and functional impairment of the cytoplasmic membrane. Topical therapy is desirable because in addition to targeting the site of infection, it reduces the risk of systemic side effects.