الفهرس | Only 14 pages are availabe for public view |
Abstract This study was designed to elucidate whether the occular alterations induced by ante mortem exposure to cadmium (Cd) and/or lead (Pb) could modify the postmortem ocular changes or alter rate of eye decomposition up to 8 h PM. To do this, a total of 72 male New Zealand White rabbits were weighed and randomly distributed into four equal groups each containing 18 animals. First group (C): control group received distilled water for 30 days. Second group (Cd): orally received 5 mg Cd Cl2 /kg bw/day for 30 days. Third group (Pb): orally received 12.5 mg lead acetate /kg bw for 30 consecutive days. Fourth group (Cd + Pb): treated with the lead acetate and Cd Cl2 at the previously aforementioned doses and durations. At the end of the dosing, 6 rabbits from each group were subjected to ophthalmologic examination of their eyes and the intraocular pressure (IOP) was recorded. Then, these animals were anaesthetized for electro physiological tests. The day following the ante mortem measurements, all animals were sacrificed via cervical dislocation after light ether anesthesia and were left exposed to air in a room with a mean temperature of 24°C and humidity 42%. All ocular observations and samples were taken from eyes of all rabbits within three postmortem intervals (PMI) (at time of death, 0, 4 and 8 h after death). At each PMI, eyes of rabbits / each group were classified into three. |