الفهرس 
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Abstract
Androgen receptor is one of the steroid nuclear receptors with
structural similarity to estrogen and progesterone receptors , but its role
in breast cancer still not well understood , especially in those with ER and
PR negative disease which lacks the response to hormonal treatment.
Many studies demonstrated the coexpression of AR and ER. with
high percentage of AR expression among ER positive breast cancer
patients.
This retrospective study was done at clinical oncology department
Menoufia University from January 2013 till December 2014. For a
sample of patients with ER negative breast cancer.
Formalin fixed and paraffin embedded blocks were gathered,
clinical and pathological data were collected from medical records and
analysed.
The aims of this study were to detect the expression of AR by
immunehistochemistry and its correlation with different clinical and
pathological characteristics. The study included 56 patients of them 37
patients were triple negative breast cancer (TNBC) In this study AR was
detected in 32% of patients with higher expression in patients with ER
negative , HER2 positive (52%).
AR positive tumors were associated with axillary nodal metastases
and Her2 expression.
In TNBC it was associated with advanced stage, nodal involvement
and worse prognosis. While it was associated with better over all survival
in ER –ve / HER2 +ve patients.
Thus Immunohistochemical determination of AR status may
provide additional information about prognosis of breast cancer, and
could be therapeutic target in ER negative breast cancer.