الفهرس 
Intrauterine Contraceptive DeviceOnly 14 pages are availabe for public view
 |  | from | 188 |  |  |
| | | from | 188 | | |
Abstract
Many studies with the CopperT380A indicated a persistent increase in menstrual blood loss of about 55%. Menorrhagia is one of the most frequent side effects of intrauterine device (IUD) use, and the most common medical reasons for premature discontinuation of the IUD . from 5% to 15% of women discontinue IUD use within one year because of bleeding. In developing countries with women who are already depleted in body iron stores may prove to be deleterious to their health.
The IUCD increases menstrual bleeding by its impact on several aspects of endometrial haemostasis. Some prostaglandins may cause increase vascularity and vascular permeability and some prostaglandins inhibit platelet activity, the increased production of prostaglandins may contribute to endometrial bleeding synthesis and release could be stimulated in IUCD exposed endometrium. IUCD induced menorrhagia might be correlated with poor contractility of spiral arterioles in spongeous layer of the endometrium. Also the increased fibrinolysis with IUCD is likely to arise as a result of damage to the capillary plexus causing increase and prolonged menstrual bleeding.