الفهرس 
General Introduction and Literature Survey
Hydrazone based on thiophene moietyOnly 14 pages are availabe for public view
 |  | from | 454 |  |  |
| | | from | 454 | | |
Abstract
New transition and lanthanide metal binary nanocomplexes as well as dispersed into silica matrix were
prepared in nano domain with crystalline or amorphous
structures for biomedical applications. Also, the mixed ligand
nano-complexes were prepared by using potassium
thiocyanate (KSCN), 8-hydroxyquinoline (8-HOqu), 2,2/-
bipyridyl (Bpy) and 1,10-phenanthroline (Phen) as
secondary ligands. The antimicrobial and antioxidant
activities for H2L1 Ligand and its binary nano-complexes
were investigated. The H2L1 and its nano-complexes (1-32)
were tested for their in vitro cytotoxicity against Ehrlich
Ascites Carcinoma cell line (EAC). Sm(III) complex-silica
xerogel nanohybrid have highest antitumor activity. The
Sm(III) complex drug storage/release process was
investigated by absorption spectra. The toxicity test on mice
showed that Binary Cu(II), Zn(II) and Sm(III) nanocomplexes as well as Sm(III) complex-silica xerogel
nanohybrid have lower toxicity than standard cisplatin.
Therapeutic effect of Sm(III) nano-complex dispersed in
silica xerogel on tumor of colon (in vivo) was studied as
antitumor drug on mice.Two novel nano-complexes [(Cu)2(L1)(NO3)2(OH2)]
(uncapped CuH) (33) and [Cu(HL1)(OH2)2(NO3)] (capped
CuCTH) (34) were synthesized by new environmentally
friendly hydrothermal method at 200oC for 48 hrs in absence
and presence of surfactant (CTAB), respectively.) The
cytotoxicity of these nano-complexes were tested against
Ehrlich Ascites Carcinoma cell line (E.A.C.). Different molar
ratio of capped CuCTH (34) and Zn(II) (1) nano-complexes
were tested for their in vitro cytotoxicity and in vivo toxicity.
۳D molecular modeling study was performed to gain better
insight on the molecular structures of ligand and its nanocomplexes.
New Series of metal nano-complexes of Zn(II),
Cu(II), Ni(II) and Co(II) with Schiff base ligand H2L2, (E)-2-
hydroxy-N/-((thiophen-2-yl)methylene)benzohydrazide were
prepared. The antimicrobial activity for complexes was
investigated. AT B3LYP/6-311G (d,p) level, Density
Functional Theory (DFT) calculations of were carried out to
investigate the optimized structure of both, the ligand and
complexes. Besides, dipole moment, and structure activity
relationship were performed and discussed. DFT calculations
confirm the practical antimicrobial results The Prepared complexes were identified by elemental,
thermal, FT-IR, UV-Vis, 1H-NMR, TEM and XRD analysis,
as well as molar conductivity and magnetic moment
measurements.