الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 90 |  |  |
| | | from | 90 | | |
Abstract
Myocardial infarction (MI), commonly known as a heart attack is defined pathologically as the irreversible death of myocardial cells caused by ischemia. Clinically, MI is a syndrome that can be recognized by a set of symptoms, chest pain being the hallmark of these symptoms in most cases, supported by biochemical laboratory changes, electrocardiographic (ECG) changes, or findings on imaging modalities able to detect myocardial injury and necrosis.
After a myocardial infarction (MI), patients are at risk for reinfarction, heart failure (HF), and sudden death. This risk is much higher in patients with left ventricular systolic dysfunction (LVSD). Although post-MI patients with LVSD have an even greater risk of mortality and morbidity.
Systolic dysfunction refers to impairment of contractility, with stroke output reduced and forward flow compromised. Systolic dysfunction is typically caused by myocyte damage such as in MI or myocarditis.
Left ventricular systolic dysfunction is present in approximately 40% of post-MI patients, and these patients do not necessarily have clinical symptoms of HF.
The platelet to lymphocyte ratio (PLR) was introduced as a potential marker to determine excess thrombotic activity and inflammation in cardiac disorders.
Increased platelet and decreased lymphocyte counts in the circulation have been associated with increased cardiovascular morbidity and mortality.
Platelet-to-lymphocyte ratio (PLR) which can be derived from the complete blood count is a novel index reflecting a systemic inflammatory burden that combines prognostic values of an individual’s platelet and lymphocyte count.
In our study we tried to make a step in understanding the role of PLR in prediction of LVSD in patients with acute myocardial infarction by making a correlation between PLR and E.F in fifty patients admitted to the Emergency Department at Menoufia University Hospitals with acute myocardial infarction,and all of these patients underwent; careful history taking,thorough clinical examination and the following investigations; CBC,CK-MB,Troponin I,ECG and echocardiography.
After the data were collected and statistically analyzed, our results showed that:
1- There was significant negative correlation between the platelet-lymphocyte ratio and left ventricular systolic dysfunction in patients with acute myocardial infarction (Table 2).
2- There was significant statistical difference between PLR groups regarding family history of diabetes (Table 3).
3- There was also significant statistical difference between PLR groups regarding family history of hypertension (Table 3).
4- There was significant statistical difference between PLR groups regarding some of blood indices (MCV and platelets) and no significant difference regarding the others (Table 4).
5- There was significant statistical difference between E.F groups regarding some of blood indices (WBCs,platelets and lymphocytes) and no significant difference regarding the others (Table 5).
6- There was no statistical difference between different PLR regarding sex, age or smoking (Table 3).
7- . There was no significant statistical difference between PLR groups regarding past and present history of hypertension or diabetes (Table 3).