الفهرس 
review of literatureOnly 14 pages are availabe for public view
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Abstract
HCV and HBV infected are responsible for the majority of chronic hepatitis and liver cirrhosis cases world wide.
Assessment of the degree of hepatic fibrosis (i.e staging) is important for several reasons : to determine the prognosis of chronic liver disease, to select patients for treatment and to monitor the success of treatment.
Liver biopsy is currently the golden staging fibrosis, but it has well documented complications of pain, bleeding and rarely death. So non invasive methods to measure severity of liver injury are clinically important where advanced liver disease is common and access to liver biopsy is limited.
Elevated serum HA may be a sensitive parameter or the prediction of cirrhosis and for the progression of liver damage.
This study aimed to evaluate the diagnostic significane of some liver fibrotic markers such as HA in patients with viral hepatitis (HBV and HCV) and in addition to correlate the blood level of these markers to the degree of liver fibrosis.
This study was done on 70 patients with chronic hepatitis 30 patients was positive for anti-HCV and negative for HBsAg,30 patients were positive for HBsAg and negative for anti-HCV and 10 cases were negative for both anti-HCV and HBsAg (healthy control). Patients were investigated for HCV and HBV serological workless liver function detection of HBV – DNA, HCV – RNA using PCR. Liver biopsies were studied for staging of fibrosis. Also, level of HA were determined to be with the results of liver biopsy.