الفهرس 
Basic Science of intra Ocular PressureOnly 14 pages are availabe for public view
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Abstract
Glaucoma is the second leading cause of blindness globally, after cataract. There are several risk factors for develpment of glaucoma, like increasing age, myopia, family history, but intraocular pressure still the most important and only treatable risk factor of glaucoma.
¬Intraocular pressure is not a constant value, it undergoes a pattern of diurnal variation .Such variations are of particular interest in glaucoma, where elevated IOP is assumed to be associated with glaucoma progression and the main option currently available for the treatment of glaucoma is the reduction of IOP, accurate determination of the IOP and the effects of therapy on it are of utmost concern not only for the management of patients with glaucoma but also for early diagnosis of patients whose randomly sampled IOP appears normal.
The evaluation of IOP is usually based on measurements performed during office hours. As IOP is considered a major risk factor for glaucoma, an undetected IOP spike could be the missing link that has not been taken into account
Our study carried out assessment of diurnal variation of IOP acting on two groups of eyes,normal and POAG .the results are shown as follows:
Regarding the normal group: the peak IOP for the normal group was reached most often at 7 pm ( mean IOP ꞊16.6 mmHg± SD꞊ 1.82 mmHg), then at 4 pm (16.4 mmHg ± 2.07mmHg).followed by 10 am,10 pm,7 am and 1 pm, with their mean IOP±SD (15.40mmHg ±1.82mmHg ),(15.2mmHg ±1.3mmHg), (15.00 mmHg ±2.24 mmHg) and(13.80 mmHg ± 2.28 mmHg) respectively.
Regarding the POAG group: the peak IOP for the POAG group was reached most often at 7 am (mean IOP =18.40 mmHg± SD= 2.41 mmHg), then at 4 pm (17.8mmHg ± 1.92mmHg).followed by 10 am,7 pm,1 pm and 10pm, with their mean IOP±SD (16.80mmHg ±2.59mmHg), (16.8mmHg ±1.92mmHg), (16.60 mmHg ±1.14 mmHg) and (15.40 mmHg ± 1.82 mmHg) respectively.