الفهرس 
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Abstract
Connective tissue diseases are heterogeneous disorders that share certain common features including: inflammation of skin, joints and other structures rich in connective tissues as well as altered pattern of immunoregulation including production of auto-antibodies and abnormalities of cell mediated immunity.
SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of non-European descent.(Anisur Rahman and David ,2008 )There is no cure for SLE. It is treated with immunosuppression,mainly with cyclophosphamide, and other immunosuppressants
This study aimed to assess role of platelet histogram and RDW as risk factor of atherosclerosis and disease activity in SLE Patients were selected from General ٌٌٌRheumatology unit of Internal Medicine Department of Assiut University Hospital.All patients had complete medical history and complete clinical examination including general and articular examination and the following laboratory tests were done: ESR, CBC, CRP,Renal function,Blood glucose level, antinuclear antibody , lipid profile , urine analysis also ECG and Carotid B-mode ultrasonography was done for all patients estimate carotid intimal thickness. to
Results revealed that RDW was higher in patients than controls p value (0.047),MPV was higher in patients than controls p value (0.011) and IMT was higher in patients than controls p value (0.020).
Results also showed that there is significant correlation between HDL and MPV,p value (0.042) also There is significant negative correlation between LDL and IMT,p value (0.049).Also RDW and LDL are independent predictor for IMT.