الفهرس 
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Abstract
The two studied groups as regard to age, group II showed significant increase as compared to group I . Also there was significant increase in group II as compared to control group (III) . As regard to sex, there were no significant differences when comparing group I and group II with control group (III), or when comparing group I with group II.
group I and group II showed significant decrease of platelet count as compared to control group (III). There was no significant difference when comparing group I with group II.
AST, ALT and GGT were significantly higher in group I and group II as compared to control group (III) and there was no significant difference when comparing group I with group II.
Alkaline Phosphatase was significantly higher in group II as compared to group III. There was no significant difference when comparing group I with group II and group III.
HCV viral load among the studied groups showed no significant difference when comparing group I with group II.
The expression level of miRNA 122 in patients’ sera (group I and group II) were significantly higher in comparison to normal control group (group III). There was no statistical significant difference in serum miRNA 122 expression level between group 1 when comparing with group II.
Serum miRNA 122 expression level showed statistically significant positive correlation with Forns and viral load in group II. On the other hand, it had no significant correlation with AST and ALT.
Four indirect markers (APRI, Forns, FIB-4, and FI) had been used in assessment of fibrosis in chronic HCV patients and comparisons between different groups and the results were as follow:
APRI, Forns, FIB-4, and FI were significantly higher in group I and group II as compared to normal control group (group III). APRI and FI showed no statistical significant difference when comparing group I with group II, While Forns and FIB-4 showed statistical significant difference when comparing group I with group II.
The APRI, Forns, FIB-4, and FI scores plus miRNA 122 were plotted in ROC curves and areas under ROC curves were used for evaluating the overall diagnostic performance for prediction of fibrosis and to demonestrate the ability of them to differentiate between mild and moderate fibrosis stages. miRNA 122 had the best performing curve for for prediction of fibrosis followed by APRI, FI, Forns and FIB-4 respectively. While FIB-4 and Forns were statistically significant in differentiating mild and moderate fibrosis. FIB-4 had a better AUROC than Forns’ score.