الفهرس 
Correlation Between FAB and WHO ClassificationOnly 14 pages are availabe for public view
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Abstract
Acute lymphoblastic leukemia (ALL) is a malignant disease caused by genetic alterations of the lymphocyte precursor cells of the bone marrow, which named it blasts. ALL is known by increasing immature lymphocytes (lymphoblast) production in the bone marrow that is preventing normal hematopoiesis. Patients with untreated ALL can due to death because of normal cells crowding out in the bone marrow and the metastasizing of cancer cells to other essential organs through peripheral blood (Bethesda, 2011).
It was suggested that a variety of different factors might have etiologically effect on the leukemogenesis. The most Important etiological factors that have risky effect on ALL can be classified to biological, physical and chemical factors (Horn, et al., 2015). Folate is a single carbon carrier fragments in the conversion of homocysteine to methionine and play important role in purine and pyrimidine synthesis (Jiang, et al., 2013).
Methylenetetrahydrofolate Reductase (MTHFR) is essential in the reduction of 5, 10-methylenetetrahydrofolate (methyleneTHF) to 5-methyltetrahydrofolate (methylTHF), which is circulatory form of folate and its a carbon donor for remethylation of homocysteine to methionine (Jiang, et al., 2013).