الفهرس 
Rosacea
Neurogenic dysregulationOnly 14 pages are availabe for public view
 |  | from | 95 |  |  |
| | | from | 95 | | |
Abstract
Rosacea is a chronic inflammatory disease of the
skin. It affects up to 15% of the general population with the
highest prevalence among adults, mostly in females with
fair skin. Symptoms present in various combinations and
degrees of severity, often fluctuating between periods of
exacerbation and remission. The complex network of the
pathophysiology of Rosacea is still unclear however, it is
thought that Inflammatory mediators from an altered innate
immune response plays a crucial role in its pathogenesis via
the cathelicidin and/or serine protease pathways. Existing
therapies only temporarily improve cutaneous symptoms
but are not curative.
Traditionally, Rosacea is considered a disease that is
limited to the skin. A few studies have observed higher risk
of cardiovascular risk factors including dyslipidemia,
hypertension, hyperglycemia and high CRP titre.
Furthermore, they are at increased risk of CAD. Although,
the mechanism underlying this increased risk is precisely
unknown, it was thought that increased atherosclerotic risk
in rosacea patients might be also related to innate immune
system dysfunction via the cathelicidin and/or serine
protease pathways.This study included 50 randomly selected Rosacea
patients of different clinical subtypes and 50 control
subjects; age and gender matched with our cases. Full
history was taken, general and local examination including;
subtype and severity evaluation, weight, height, BMI, waist
circumference, blood pressure were measured.
Investigation including, total lipid profile, fasting blood
sugar and CRP titre. All cases and controls were assessed
and diagnosis of metabolic syndrome was made according
to ATP III criteria.
Statistical analysis revealed a statistically significant
increase in risks of high cholesterol, triglycerides, LDL,
fasting blood glucose and low HDL in patients of rosacea in
comparison with healthy controls, however; there was no
significant difference in cases and controls as regard the
waist circumference, the BMI, the blood pressure and the
CRP titre. After implication of ATP III criteria in cases and
controls it revealed that there was a highly significant
difference between cases and controls as regard incidence
of metabolic syndrome with higher values in cases than
controls. Incidence of metabolic syndrome was
significantly high in moderate to severe grade of rosacea
versus mild grades of rosacea. There were no significant
difference in incidence of metabolic syndrome in relation to
Rosacea subtype and disease duration.We suggest that rosacea patients are at increased risk
of developing cardio-vascular risk factors and are
accordingly more liabe to have metabolic syndrome and
that moderate to severe grade of Rosacea patients are more
suceptable to have metabolic syndrome.