الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Delivering cytotoxic agents to cancer is accompanied with several challenges due to the lake of selectivity and specificity of these agents, where they act against both normal and cancer cell types. However, the ability to target chemotherapeutic agent to cancer without affecting normal cells is promising. On the other hand, the use of nanopartculate systems for this purpose could overcome this challenge. Doxorubicin hydrochloride, an anticancer agent that is known for its severe side effects mainly cardiomyopathy and renal failure which limits its use. Herein we developed a nano system based on gold nanoparticles for the delivery of doxorubicin HCl to cancer. The in vitro release behavior of the developed system showed that more than 60 % of the loaded doxorubicin HCl was released in acetate buffer pH 5, on the other hand, 10% of the drug was only released in PBS pH 7.4 within 48 hours. Cell viability assay against hepatocellular carcinoma cells (Hep G2 cells) revealed that up to 13.2% of cells were viable at Dox-loaded GNPs concentration of 8 µg/ml, comparatively, 6.1% of cells were viable at the same concentration of free Dox. The developed system was tested against normal cell lines (HL-7702) and found to be less toxic than the free drug. The developed system seems to be advantageous as cancer drug delivery tool with minimal side effects compared to the parent drug.