الفهرس 
PRE--DIIABETESOnly 14 pages are availabe for public view
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Abstract
Objectives: Vitamin D – a fat soluble vitamin- is best known for its role in calcium regulation and bone metabolism. Recently, however, an emerging body of evidence has suggested that vitamin D may have previously-unrecognized effects on a variety of physiologic processes, including those relating to glucose homeostasis.The aim of the present study is to evaluate the correlation between serum vitamin d levels and blood sugar levels in Egyptian pre-diabetics, naïve diabetics and uncontrolled diabetics and assess efficacy of vitamin d supplementation on glucose metabolism as a cheap and safe regimen of prevention and control of type 2 diabetes.
Methods: This study was conducted on 150 subjects who were divided into 3 groups:pre-diabetes, drug-naïve diabetes and type 2 diabetes.All selected subjects were subjected to full medical history and full clinical examination and laboratory tests included fasting blood glucose, oral glucose tolerance test, HbA1c, fasting insulin, lipid profile and 25 (OH) cholecaciferole
Results and conclusion:the present study showed that:Levels of vitamin D were decreased in all studied groups. No significant changes of FBS, PPBS or HbA1c, fasting plasma insulin and HOMA-IR in patients with pre-diabetes, type 2 diabetes either drug naïve or on current anti-diabetic treatment with regard to vitamin D supplementation. No significant changes of blood pressure and lipid profile in patients with pre-diabetes, type 2 diabetes either drug naïve or on current anti-diabetic treatment with regard to vitamin D supplementation. On- statistically significant negative relations between vitamin D levels and blood glucose. A significant negative correlation between vitamin D and age in the pre-diabetic group and type 2 diabetes group on treatment.
Key words: 25(OH) cholecalciferole, pre-diabetes and type 2 diabetes mellitus
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