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Abstract The present investigation was designed to evaluate the effect of cannabis sativus plant extract on neurotransmitters in brain tissue of male albino rats. Experimental design: The present study was carried out on 150 males healthy slbino rats, 1 month old and had an average weight 11 Ogm. They were reared under the same environmental and nutritional conditions at separated clean cages. They were also kept under observation for 15 days before the experiment. They were divided into 6 groups: Groupl: Included 24 rats, which were injected intra peritonially with cannabis sativus extract for seven successive days. The rot of this gruqp were subdivided int 2 group: group la: included 12 rats: injected with 0.1 ml cannabis lotal extract (low dose) intra peritonially once a day for 1 weak ~rain tissue samples were collected 4 hours after the last injected oose. group lb: included 12 rats: injected with 0.2 ml cannabis total extract (high dose) intra peritonially once a day for 1 weak hain tissue samples were collected 4 hours after the last injected dose. |