الفهرس 
Structure of Peripheral NerveOnly 14 pages are availabe for public view
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Abstract
Effect of Pulse Configuration of Induced Current on Sciatic Nerve Regeneration. Abeer abd Alrahman
Mohamed, Faculty of Physical Therapy, Cairo Unversity. Supervisor: Prof.Dr; Wadida Hassan Abd
Elkader, Prof.Dr. Fadel Mohamed Ali and Prof. Dr.Soheir assadd Filobbos. Ph.D. Thesis. Basic
Science Department, 2005.
The purpose of this work was to study the effect of induced electrical current with specific
pulse configuration (shape, frequency and amplitude) that nearly resonates with the pulse
for biological excitation of the sciatic nerve and Nerve Growth Factor (NGF) on regeneration of
rat sciatic nerve. Surgical crushing of the left sciatic nerve of sixty rats was done. The rats
were divided according to treatment into two equal groups; (1) Untreated control group and (2)
Treated group received specific pulse determine by preliminary study for 45 min daily for up to
five weeks. This pulse had RC-Square Amplitude Modulating Wave (RC-SAMW) shape with 2.5 Hz
frequency and 2.5 Vpp amplitude carried on 0.5MHz wave carrier frequency and 10 Vpp
amplitude. The regeneration rate was measured by Sciatic Function Index (SFI), Toe Spread
Reflex (TSR) and histo-morphometeric study after one, three and five weeks post operative. The
results indicated that SFI and TSR improved progressively in Treated group and the
improvement % was 83% and 89% compared to 68% and 71%% in Untreated group after five
weeks, respectively. The number of myelinated nerve fiberI standard
measuring frame, area and area % of myelination and optical density
of sum and mean grey of myelination were significantly higher in Treated group than Untreated
one , where the P value < 0.0001 ,
0.001, 0.01 and 0.001 consequently after five weeks. The study concluded that induced electrical
current with 2.5 Hz RC-SAMW
enhances early function and morphologic regeneration of the
crushed sciatic nerve, probably by accelerating axonal degeneration, stimulating nerve sprouting
and myelination.