الفهرس 
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Abstract
Nausea and vomiting of pregnancy, commonly known as” morning sickness ” affects approximately 50%
to 90% of all pregnant women in the first trimester. The typical onset is between 4-8 weeks of
gestation, with symptoms continuing until .14-16 weeks. The exact cause of hyperemesis gravidarum
is unknown however many theories have been propounded. H. Pylori is curved or spiral shaped, Gram
negative, non capsulated non spore-forming bacillus. The organism measures (o.5-1) urn. in width
and (2.5-5.0) urn. in length. Helicobacter pylorus plays a major role in abdominal symptoms and
gastro-duodenal pathology. An association between infection with H. pylori and hyperemesis
gravidarum may be present.
This work aimed at assessing the possible relation between helicobacter pylori infection and
hyperemesis gravidarum.
This study included 60 pregnant women during their first trimester divided into two equal groups
according to the presence or absence of hyperemesis gravidarum: group I; 30 patients (hyperemetic
group)., group 2; 30 women (non-hyperemetic group).
The two groups were subjected to the fOllowing:
Full history taking, Clinical examination, transabdominal pelvic sonogram to: Asses fetal life and
gestational age and to exclude gestational trophoplastic disease, multiple gestation. 5 ml venous
blood samples were collected and tested for H.pylori seropositivity IgG using ELISA technique.
Results of this work showed that :
Ther was no significant statistical difference in maternal age, gestational age and parity between
hyperemetic and non-hyperemetic groups.
In this study there was no significant statistical difference between
group [1] patients with hyperemesis gravidarum and group [II] control group ’’without hyperemesis
gravidarum’’ as regards maternal weight.
There was a highly significant statistical difference between hyperemetic and non-hyperemetic
groups as regards H.pylori IgG Ab titer and IgG seropositivity (71.7% and 16.6% respectively).
from this study we can conclude that there is a positive significant correlation between H.pylori
IgG seropositivity and the risk of occurrence of hyperemesis gravidarum.
Recommendation:
from this study it is recommended that the treatment of H.pylori infection may reduce the risk of
hyperemesis gravidarum and its complications. Women who are considering pregnancy in the near
future should be tested for helicobacter pylori using IgG Ab, and the infection should be
controlled before pregnancy to decrease the incidence of hyperemesis gravidarum and its
complications.