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Abstract Helicobacter pylori is one of the most common infections that colonizes the gastric mucosa.(22) Its prevalence is about half of the population. It has the capability to induce chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue lymphoma.(14) When the bacterium colonizes the gastric mucosa, abundant amounts of reactive oxygen species (ROS) like superoxide anion and reactive nitrogen species (RNS) like nitric oxide (NO) are generated within the gastric mucosa leading to gastric mucosal oxidative stress which represents one of the most important mechanisms in the pathology of helicobacter pylori infection.(241) These oxygen free radicals also cause lipid peroxidation leading to production of large amounts of malondialdehyde.(231) In the inflamed tissues caused by Helicobacter pylori, the cells produce antioxidant enzymes like catalase, glutathione peroxidase and superoxide dismutase to defend themselves from the increasing amounts of free radicals produced by the bacterium to induce pathological changes.(232) The aim of this study was to evaluate the oxidative stress condition in the gastric mucosa of Helicobacter pylori-infected children. PATIENTS AND METHODS This study was carried out upon 30 children infected with Helicobacter pylori with their ages ranged from 7-15 years with a mean value of 11 ± 2.65 years who were attending the Hepatology Unit,. |