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Abstract Fluorescein angiography (FFA) and optical coherence tomography (OCT) scans are important tools used in the examination and management of retinal diseases. These investigative modalities complement to each other, and many situations require both imaging methods to make the correct diagnosis and treatment plan. This article compares the two technologies in various clinical situations. Fluorescein angiography provides retinal circulation details, and OCT offers high-quality anatomic images. Fluorescein angiography is invasive, nonquantitative, and subjective, with limited use for patients with small pupils or insufficient media clarity. Optical coherence tomography is objective and is not so much affected by pupil size or media clarity. Registration of OCT scans helps clinicians properly assess patients during follow-up visits. Both diagnostic tools depend heavily upon patient cooperation. Both are useful, and often complimentary, in the diagnosis and management of a variety of retinal disorders. The aim of work is a comparison between fluorescein angiography and optical coherence tomography in detection of macular changes of retinal vascular disorders and to detect points of strength and weakness in each of them The present study is a observational, retrospective, longitudinal study. Patients were recruited the outpatient retina clinic at Ophthalmology Department; Tanta University during the period from December 2014 to May. |