![]() | Only 14 pages are availabe for public view |
Abstract Preeclampsia is a multi-system disorder characterized by the new onset of hypertension and either proteinuria or end-organ dysfunction in the last half of pregnancy Pre-eclampsia may be life-threatening for both mother and child, increasing both fetal and maternal morbidity and mortality. Pre-eclampsia has a complex pathophysiology, the primary cause being abnormal placentation. Defective invasion of the spiral arteries by cytotrophoblast cells is observed during pre-eclampsia. Increased sensitivity to vasoconstrictior agents induce uterine artery resistance and thus chronic placental ischemia and oxidative stress. |