الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Samples of pure chitosan and other samples filled with different concentrations of pyrazol moiety drug containing were prepared and investigated using different characterization techniques. Fourier transform infrared spectroscopy (FTIR) and UV/Vis. spectroscopic measurements were employed to retrace the structural changes accompanied with change in the drug content and/or gamma irradiation doses. It was found that main characteristic bands due to characteristic vibrational groups remain unchanged while the optical band gap and intensity of optical absorption were changed with drug concentration and radiation doses indicating crosslinking process. The crosslinking degree was found to be increased with radiation dose. X-ray diffraction (XRD) and scanning electron microscopy (SEM) for prepared samples showed a homogenous distribution for lower concentrations. A sharp diffraction peaks at 8.9 and 14.7 in XRD with needle like structure in (SEM) for sample that contains 20 wt% of drug indicates the saturation condition.
Some Hypotheses have been suggested about the reaction mechanisms between chitosan and pyrazolic drug using a theoretical modeling approach. DFT modeling approach confirmed that the more dominant reaction mechanism was by replacing of sulfur atom instead of nitrogen atom from chitosan structure. These results was compared to the experimental FTIR data and confirmed. The swelling rate behavior of the prepared samples with different concentrations at different pH’s was comparable to that of sustained release behavior especially after crosslinking process using gamma irradiation.Recommendation
Prepared samples were recommended to be used as antibacterial and antifungals vaginal suppository for sustained drug release at acidic pH (4.5).