الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Gold nanoparticles (GNPs) have emerged as a promising delivery system for different drugs. GNPs were prepared by citrate reduction method. To improve their in-vivo stability and to avoid uptake by the reticuloendothelial system, thioalkylated polyethylene glycol including methoxy and amino polyethylene glycol-undecyl mercaptan were synthesized. Furthermore polyethylene glycol terminated with amine group can be used for conjugation with 5-fluorouacil-1-acetic acid through amide bond for functionalization of GNPs surface. The synthesis of GNPs using curcumin as a reducing and stabilizing agent was also described. Curcumin is a plant origin that has several pharmacological actions like antitumor, antibacterial and anti-inflammatory effects.
The antitumor activity of curcumin capped GNPs and 5-fluorouracil loaded on GNPs was evaluated by cell culture method using human breast cancer cell line and compared to the same drugs in typically administered free forms or as prepared GNPs. The results showed an improvement in the drug anticancer activity upon loading on GNPs compared to free drugs and plain GNPs.