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Abstract Vitiligo is a disease that causes depigmentation of parts of skin which occurs when melanocytes die or unable to function. Incidence worldwide is 1-2%. Vitiligo is classified as segmental and non-segmental disease. There are many methods for its assessment. Homocysteine is sulfer containing amino acid derived from the metabolism of methionine via methyle group metabolism. Homocysteine normal metabolism protects the cell against oxidative stress. Abnormalities in homocysteine metabolism are associated with many diseases. In conclusion, our results have suggested that homocysteine levels were found to be higher in vitiligo patients than controls, in patients with larger surface areas, and appear to be related to disease activity. |