الفهرس 
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Abstract
Burn injuries are one of the most common and devastating forms of trauma. They represent a serious global public health problem accounting for high mortality rate annually. Following the initial period of shock, burn wound infection is the major complication in burn injuries and 75% of the mortality associated with burn injuries is related to sepsis especially in developing countries of which Egypt is a part. This study aimed to investigate the multidrug resistance of bacteria isolated from burn wound infections, their mechanisms of resistance and ways that can be employed to counteract such resistance. This study also designed to find whether there is a correlation between resistance to antibiotics and NAAA in isolated pathogens. A total of 240 non-repetitive specimens, representing 110 clinical, 70 hospital environmental and 60 HCWs specimens, were collected during the period from April 2013 to December 2013 from the burn unit of Hehia General Hospital, Sharkia, Egypt. All specimens were collected aseptically and transported to the microbiology laboratory, where they were immediately processed. Positive growth cultures were found in 107 (97.3%), 40 (57.1%), 25 (41.6%) specimens of clinical, hospital environmental and HCWs specimens, respectively. A total of 160 clinical, 54 environmental and 29 HCWs bacterial isolates were recovered. Complete identification of all isolates was based mainly on the morphological, microscopical characteristics and the biochemical tests.
The predominant pathogens recovered from burn patients were S. aureus (22.5%), P. aeruginosa (20.6%), followed by K. pneumoniae (15.6%), CoNS (12.5%), P. mirabilis (8.9%), and A. baumannii (6.9%). Other pathogens recovered were E. coli, E. cloacae (4.4% each), C. freundii, K. oxytoca (1.8% each) and P. vulgaris (0.6%). Regarding environmental specimens, the isolates recovered were S. aureus (29.6%), P. aeruginosa (22.2%), K. pneumoniae (14.8%), CoNS (11.1%), P. mirabilis, A.baumannii (5.5% each), K. oxytoca (3.7%), P. vulgaris, E. coli, E. cloacae and C. freundii (1.9% each). While, P. aeruginosa (34.6%), S. aureus (31%), CoNS, K. pneumoniae (10.4% each), P. mirabilis, K. oxytoca, E. coli, and E. cloacae (3.4% each) were the isolates recovered from HCWs specimens.