الفهرس 
• Cystatin COnly 14 pages are availabe for public view
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Abstract
Introduction: Renal dysfunction is common in patients with liver cirrhosis which occurs in about 19% of hospitalized patients with cirrhosis due to several factors. Several reports have suggested that increased serum Cystatin C levels are more sensitive for detecting renal dysfunction in patients with liver cirrhosis than increased serum creatinine levels. Aim of the study: This study will be performed to assess the value of measurement of serum Cystatin C in the detection of renal dysfunction in patients with cirrhotic ascites and normal serum creatinine. Patients and Methods: The present study was carried out on fifty (50) patients with cirrhotic ascites and normal serum creatinine levels. These patients were chosen from those ”admitted at Gastroenterology and Hepatology Unit and those recruited from Hepatology clinic at Department of Internal Medicine, Ain Shams University. Results: Results of the present study showed that serum cystatin C was a good mirror of renal function having the advantage of not be dependent on age, gender and muscle mass. Conclusion: from the previous study, it can be concluded that Cystatin C level is more sensitive for detecting renal dysfunction in patients with liver cirrhosis than increased serum-creatinine levels & its level assessment appeared to be a good alternative to serum creatinine in these patients. Recommendations: Patients with liver cirrhosis should have regular estimation of serum cystatin C level for prognosis, dosage assessment of potentially nephrotoxic drugs and recognition of changes in glomerular filtration rate (GFR) to detect early affection of their renal functions.