الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
 |  | from | 158 |  |  |
| | | from | 158 | | |
Abstract
The present study was undertaken to analyze the interactive role of serum alfafetoprotein (AFP), soluble endoglin & p53 to predict patients with chronic hepatitis B virus (HBV), early liver fibrosis & early stage hepatocellular carcinoma (HCC).
It includes a total of 49 patients (42 males & 7 females ), that were selected from the attendants of the outpatient clinic of Tropical Medicine Department , Assuit University Hospital .The study was subdivided into 4 groups (18 healthy controls, 13 chronic HBV infection , 11 early stage liver fibrosis & 25 stage II HCC complicating cirrhosis).Their age ranged from 44-77 years . All of them had no previous treatment for about 6 months .Routine laboratory investigations including viral markers , liver function tests , blood sugar ,kidney function tests & AFP were done using standard methods .Serum levels of p53 protein , soluble endoglin were determined using ELISA kits .
The results showed that there was a male predominance among all patients .Also, it was observed that HCC- patients exhibited the highest percentage of active smoking (44%) & all had past history of cirrhosis. It is concluded that AFP ,p53 & endoglin are non– invasive inexpensive alternative parameters that could together successfully predict & differentiate between chronic HBV ,early liver fibrosis and early stage HCC in the following successive order : AFP˃P53˃endoglin where AFP is the more sensitive & specific one followed by P53 then endoglin.
The P53 & endoglin could not discriminate patients with chronic HBV from normal controls.