الفهرس 
• Pathogenesis of Psoriatic Arthritis (PsA)Only 14 pages are availabe for public view
 |  | from | 200 |  |  |
| | | from | 200 | | |
Abstract
Background/Purpose: 14-3-3 proteins are a conserved family of 7 isoforms with diverse cellular functions found predominantly intracellularly. The 14-3-3η isoform is expressed extracellularly in the joints of patients with rheumatoid arthritis (RA) and expression in both serum and joint fluid correlates strongly with expression of metalloproteinases. 14-3-3η activates proinflammatory signalling cascades and inflammatory mediators relevant to the pathogenesis of RA.Psoriatic arthritis one of the destructive arthropathy and no specific marker is available for diagnosis.We investigate the possible role of 14-3-3 eta as a diagnostic and severity marker in PsA.
Methods: Assays to measure the levels of 14-3-3 eta protein in serum of 20 PsA patients and 10 healthy adults matched to both age and sex and compare the 14-3-3 eta levels in the two groups and comparing the levels with clinical severity indices including PASI, NAPSI and BASDAI score and also with laboratory investigations including ESR, CBC, CRP, FBG, kidney function tests, liver function tests and serum uric acid.
Results: significantly higher serum levels of 14-3-3 eta protein in PsA patients compared to the controls. Statistically significant positive correlation between 14-3-3 eta level and disease duration (P<0.001) denoting its possible role as a marker for chronicity. Statistically significant positive correlation between 14-3-3 eta levels and severity indices (p<0.001) (r 0.946) denoting its role as severity marker. Statistically positive correlation with ESR (p<0.001) (r 0.838) and CRP (p<0.05) (r 0.595) denoting its role as an activity marker.
Conclusion: Extracellular 14-3-3 eta protein has been described as PsA diagnostic, severity and activity biomarker with prognostic and therapy monitoring applications.