الفهرس | Only 14 pages are availabe for public view |
Abstract Soft tissue sarcoma (STS) represents a heterogeneous group of malignancies. Any patient with a soft tissue mass that is increasing in size, has a size >5cm or is deep to the deep fascia,should be referred to a diagnostic centre with a formally constituted Sarcoma multidisciplinary team (MDT). Appropriate treatment begins with appropriate staging studies followed by a carefully planned and well executed biopsy. Magnetic resonance imaging (MRI) and core needle biopsy are recommended prior to definitive surgery. Imaging of the thorax by CT scan for lung metastases should be done prior to radical treatment. Treatment plans should be made in a multidisciplinary setting involving input from the surgeon, medical oncologist, radiation oncologist, radiologist and pathologist. Limb salvage surgery is the standard of care. Radiation therapy in combination with surgical resection is highly effective at achieving local control. The use of chemotherapy is evolving but currently is not well-defined For patients with borderline resectable tumors, preoperative treatment with chemotherapy or radiotherapy should be considered dependant on individual histology. Post-operative radiotherapy is recommended following surgical resection of the primary tumor for the majority of patients with high-grade tumors, and for selected patients with large or marginally excised, low-grade tumors |