الفهرس 
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Abstract
This thesis comprises five chapters. The first one is an introduction that comprises a hint on biological view of inflammation and different drugs used in its treatment. It also includes the different methods adopted to synthesize some diaryl pyrazole and triaryl pyrazoline derivatives.
The second chapter deals with the aim of the work and Schemes those have been carried out to obtain the target diarylpyrazole and triarylpyrazoline derivatives.
The third chapter contains three parts. The first part deals with the discussion of the experimental work for the preparation of target compounds. Claisen Schmidt condensation of 3-or 4-nitroacetophenone derivatives Ia-b with different aromatic aldehydes IIa-h afforded chalcone dervatives IIIa-p which upon cyclization with 4-methanesulfonylphenylhydrazine hydrochloride (IV) afforded 1,3,5-triarylpyrazolines (Va-p).
On the other hand, cyclization of 2-(ethoxymethylene)malononitrile (VIII) with 4-methanesulfonylphenylhydrazine (IV) afforded 5-amino-1-(4-(methanesulfonyl)phenyl)-1H-pyrazol-4-carbonitrile (IX).
Additionally, reaction of 5-amino-1-(4-(methanesulfonyl)phenyl)-1H-pyrazole-4-carbonitrile (IX) with different aromatic aldehydes in precence of morpholinium hydrogen sulphate (X) afforded the targat 5-substituted-amino-1-(4-(methanesulfonyl)phenyl)-1H-pyrazole-4-carbonitrile (XIa-h).
The second part of the third chapter contains the theoretical discussion of biological activity of twenty four synthesized target compounds Va-p and XIa-h. The discussion includes also in vitro cyclooxygenase inhibitory