الفهرس 
Chapter I ( Zinc overview)Only 14 pages are availabe for public view
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Abstract
Zinc is an essential mineral for human health. It is relatively abundant in nature, yet at the same time, overwhelming data suggest that zinc deficiency is one of the most prevalent micronutrient deficiencies worldwide by using data from a recent national micronutrient survey in Vietnam zinc deficiency among children is four times more prevalent than iron deficiency (Wieringa et al., 2015)
The importance of micronutrients in health and nutrition is undisputable, and among them, zinc is an essential element whose significance to health is increasingly appreciated and whose deficiency may play an important role in the appearance of diseases. Zinc is one of the most important trace elements in the organism, with three major biological roles, as catalyst, structural, and regulatory ion. Zinc-binding motifs are found in many proteins encoded by the human genome physiologically, and free zinc is mainly regulated at the single-cell level. Zinc has critical effect in homeostasis, in immune function, in oxidative stress, in apoptosis, and in aging, and significant disorders of great public health interest are associated with zinc deficiency (Chasapis et al., 2012).
The association of low plasma zinc levels plasma zinc with critical illness has become increasingly evident over the past several years, leading to a growing interest in investigating the potential therapeutic benefit of zinc supplementation. The biologic functions of zinc are varied, but in the setting of critical illness, its involvement in the maintenance of intact immune function as well as its role in glucose homeostasis may be particularly relevant (Cvijanovich et al., 2015).