الفهرس 
Toll like receptorsOnly 14 pages are availabe for public view
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Abstract
Background: Respiratory defenses against infection involve a diverse and complex system. Multiple factors determine the frequency and nature of these illnesses. Patients with Primary immunodeficiency are more susceptible to infections of any kind, mainly respiratory tract infections which lead to permanent lung damage in 20-40% of patients.
Aim of the work: This study aims to define commensal and pathogenic organisms in lower respiratory tract in cases with recurrent or chronic respiratory tract infections with or without primary immune deficiency and correlate this to the choice of prophylactic antibiotic therapy.
Subjects and methods: This is a cross sectional case-control study. Twenty B cell ID patients with respiratory tract infections were compared to 20 non immunodeficiency patients with recurrent chest infections and twenty age and sex matched healthy controls. Patients were subjected to full history taking, complete physical examination and laboratory investigations including complete blood count and immunoglobulins. CT scan of the chest with contrast, pulmonary function tests (PFTs) and BAL fluid culture and sensitivity were performed to patients with recurrent and / or chronic chest infections with or without B cell defect.
Results: Staphylococcus aureus was the most commonly isolated organism (20%) in B cell immunodeficiency patients in our study, followed by Klebsiella pneumonia and Pseudomonas aeruginosa (in 15% each) then Streptococcus pneumoniae and E coli (10% each one), While Pseudomonas aeruginosa was the most common isolated organism (25%) in non immunodeficient patients, followed by Klebsiella pneumoniae (in 15%), E coli in 10%, and Staphylococcus aureus also in 10%,
Conclusion: Pseudomonas aeruginosa was the most common isolated organism in patients with respiratory tract infections without humoral ID, while Staphylococcus aureus was the most commonly isolated organism in humoral ID patients with respiratory tract infections.