الفهرس 
General IntroductionOnly 14 pages are availabe for public view
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Abstract
Potential Applications of Nanotechnology in Non-invasive Drug Delivery This thesis is a focus highlighting on two vital drugs in the treatment of hormonal disturbances (Progesterone) and tuberculosis (Rifampicin). In spite of their importance as afirst line choice, they are suffering from obstacles in oral and parenteral delivery. The current thesis investigated the relevance of nanomedicine to improve the efficacy of these two drugs via incorporation into different novel drug delivery systems. Moreover, in an attempt to
circumvent the drawbacks associated with their oral or parenteral delivery routes, their noninvasive performances were investigated. The work in the current thesis was divided into two parts:PART ONE: Relevancy of Nanotechnology for Non-invasive Management of Hormonal Disturbances Progesterone is a naturally occurring progestin secreted by the corpus luteum, a prototype of the progestins and still the recommended choice for hormonal disturbances management. Unfortunately, delivery of progesterone via the oral or parenteral routes faces massive obstacles because of poor bioavailability, short half-life duration, rapid clearance,hepatic metabolism and non-compliance patient attitude. Therefore, the major goal of the current part encompasses the design and characterization of a novel nanoscopic transdermal system for progesterone delivery with the idea of enhancing its therapeutic activity and
sustaining its effect for a longer period. The work in this part was sub-classified into two
chapters:
Chapter One:
Novel Self-assembled Liquid Crystalline Nanoparticles for Transdermal Delivery of
Progesterone: Development, Quality by Design In-vitro Optimization and Ex-vivo
Permeation Studies
The present chapter aimed to elaborate novel self-assembled liquid crystalline
nanoparticles (LCNPs) for management of hormonal disturbances following non-invasive
transdermal delivery of progesterone. The LCNPs bearing progesterone were prepared via a
simple processing technique utilizing different glyceryl monoglycerides. Fabrication and
optimization of progesterone-loaded LCNPs were assessed via a quality by design approach
based on 23 full factorial design. The design includes the functional relationships between
independent processing variables and dependent responses of particle size, polydispersity
index, zeta potential, % cumulative drug release after 24 h and ex-vivo transdermal steady
flux. Morphological elucidation of the prepared novel system was examined using
transmission electron microscopy. The developed nanocarrier was subjected to a stability
study within a period of 3 months at different storage temperatures.